RecruitingPhase 4NCT06372925

Intravascular Imaging Study of the Effect of Inclisiran on Plaque in Patients With Acute Myocardial Infarction

A Multi-Center, Randomized, Open-label, Parallel, Controlled Phase Ⅳ Clinical Trial to Evaluate the Effect of Inclisiran on Coronary Atherosclerotic Plaque in Patients With Acute Myocardial Infarction and Elevated Low-density Lipoprotein Cholesterol


Sponsor

Novartis Pharmaceuticals

Enrollment

318 participants

Start Date

Jul 9, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study is to evaluate the effect of Inclisiran on coronary atherosclerosis using intravascular ultrasound (IVUS) and optical coherence tomography (OCT) in patients with acute myocardial infarction and elevated low-density lipoprotein cholesterol (LDL-C).


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called IVUS/OCT, a drug called atorvastatin, and others for people with plaque, atherosclerotic. The study is currently recruiting participants at 20 locations. People eligible for this study include aged 18 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGatorvastatin

20mg atorvastatin PO

PROCEDUREIVUS/OCT

performed the IVUS/OCT at baseline and Day 360

DRUGinclisiran

Inclisiran 284mg SC


Locations(20)

Novartis Investigative Site

Hefei, Anhui, China

Novartis Investigative Site

Fuzhou, Fujian, China

Novartis Investigative Site

Guangzhou, Guangdong, China

Novartis Investigative Site

Guangzhou, Guangdong, China

Novartis Investigative Site

Guangzhou, Guangdong, China

Novartis Investigative Site

Shenzhen, Guangdong, China

Novartis Investigative Site

Zunyi, Guizhou, China

Novartis Investigative Site

Harbin, Heilongjiang, China

Novartis Investigative Site

Zhengzhou, Henan, China

Novartis Investigative Site

Wuhan, Hubei, China

Novartis Investigative Site

Nanchang, Jiangxi, China

Novartis Investigative Site

Changchun, Jilin, China

Novartis Investigative Site

Dalian, Liaoning, China

Novartis Investigative Site

Jining, Shandong, China

Novartis Investigative Site

Xian, Shanxi, China

Novartis Investigative Site

Chengdu, Sichuan, China

Novartis Investigative Site

Wenzhou, Zhejiang, China

Novartis Investigative Site

Beijing, China

Novartis Investigative Site

Lanzhou, China

Novartis Investigative Site

Tianjin, China

View Full Details on ClinicalTrials.gov

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NCT06372925


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