RecruitingPhase 3NCT06372964

Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients

A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Lumateperone for the Treatment of Major Depressive Episodes (MDEs) Associated With Bipolar I or Bipolar II Disorder (Bipolar Depression) in Pediatric Patients Aged 10 to 17 Years


Sponsor

Intra-Cellular Therapies, Inc.

Enrollment

384 participants

Start Date

May 13, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is a multicenter, randomized, double-blind, placebo-controlled study in pediatric patients who are experiencing major depressive episodes (MDEs) associated with a primary diagnosis of bipolar I or bipolar II disorder as confirmed by Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL), according to criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM 5).


Eligibility

Min Age: 10 YearsMax Age: 17 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a medication called lumateperone for treating bipolar depression in children and teenagers. Lumateperone is already approved for adults, and this trial aims to establish whether it is safe and effective for younger patients. **You may be eligible if...** - Your child is between 10 and 17 years old - They have been diagnosed with bipolar I or bipolar II disorder and are currently in a depressive episode (not psychosis) - They have had at least one past manic or hypomanic episode - The current depressive episode has lasted 4 weeks to 12 months - A parent or guardian is able to provide consent and the child can provide assent **You may NOT be eligible if...** - Your child has a very low depression severity score at screening - They are currently experiencing psychosis or active suicidal ideation with a plan - They have significant heart, liver, or kidney problems Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLumateperone

Lumateperone administered orally, once daily.

DRUGPlacebo

Matching placebo administered orally, once daily.


Locations(59)

Clinical Site

Dothan, Alabama, United States

Clinical Site

Little Rock, Arkansas, United States

Clinical Site

Anaheim, California, United States

Clinical Site

Redlands, California, United States

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Sacramento, California, United States

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San Diego, California, United States

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West Covina, California, United States

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Colorado Springs, Colorado, United States

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Gainesville, Florida, United States

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Hialeah, Florida, United States

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Homestead, Florida, United States

Clinical Site

Miami, Florida, United States

Clinical Site

Miami, Florida, United States

Clinical Site

Miami, Florida, United States

Clinical Site

Miami, Florida, United States

Clinical Site

Miami, Florida, United States

Clinical Site

Miami, Florida, United States

Clinical Site

Miami, Florida, United States

Clinical Site

Miami, Florida, United States

Clinical Site

Miami, Florida, United States

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Miami Gardens, Florida, United States

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Miami Lakes, Florida, United States

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Miami Lakes, Florida, United States

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Miami Springs, Florida, United States

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Orlando, Florida, United States

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West Palm Beach, Florida, United States

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Atlanta, Georgia, United States

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Decatur, Georgia, United States

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Lawrenceville, Georgia, United States

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Savannah, Georgia, United States

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Chicago, Illinois, United States

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Indianapolis, Indiana, United States

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Baltimore, Maryland, United States

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Bloomfield Hills, Michigan, United States

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Saint Charles, Missouri, United States

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Lincoln, Nebraska, United States

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Kinston, North Carolina, United States

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Avon Lake, Ohio, United States

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Cincinnati, Ohio, United States

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Garfield, Ohio, United States

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Westlake, Ohio, United States

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Oklahoma City, Oklahoma, United States

Clinical Site

Oklahoma City, Oklahoma, United States

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Austin, Texas, United States

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Flower Mound, Texas, United States

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Frisco, Texas, United States

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Houston, Texas, United States

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Houston, Texas, United States

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Richmond, Texas, United States

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Richmond, Virginia, United States

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Bellevue, Washington, United States

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Everett, Washington, United States

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Ahmedabad, India

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Aurangabad, India

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Nashik, India

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Varanasi, India

Clinical Site

Belgrade, Serbia

Clinical Site

Niš, Serbia

Clinical Site

Novi Sad, Serbia

View Full Details on ClinicalTrials.gov

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NCT06372964


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