RecruitingNot ApplicableNCT06373016

Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder


Sponsor

Stony Brook University

Enrollment

100 participants

Start Date

Jan 26, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to test how specific components of diet affect brain function and behavior for individuals with bipolar. The main question it aims to answer is how glucose and ketones each affect the brain's response to risk and reward. Participants will be asked to provide blood (to assess baseline measures of how the body uses energy), and then to receive two MRI scan sessions, on separate days. During each MRI scan session, participants will play three games, from which they can win money, before and after drinking glucose (on one day) or ketones (on the other day). Investigators will compare individuals with and without bipolar to test whether the two groups differ in how their brains use energy, and to test how the brain's use of energy affects behavior.


Eligibility

Min Age: 18 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Glucose and Ketones for people with bipolar disorder and bipolar disorder type 1. The study is currently recruiting participants at 3 locations. People eligible for this study include aged 18 Years to 45 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTGlucose

A glucose drink is administered midway through one of the scan sessions.

DIETARY_SUPPLEMENTKetones

A ketone drink is administered midway through one of the scan sessions.


Locations(3)

McLean Hospital

Belmont, Massachusetts, United States

Martinos Center for Biomedical Research, Building 149, 13th Street

Charlestown, Massachusetts, United States

Laufer Center for Physical and Quantitative Biology , Stony Brook University

Stony Brook, New York, United States

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NCT06373016


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