Resistance Training and Corticospinal Excitability in Multiple Sclerosis
Effects of Supervised Progressive Resistance Training on Central Nervous System Functioning (Corticospinal Excitability) and Walking Capacity in Persons With Multiple Sclerosis
University of Aarhus
54 participants
May 1, 2024
INTERVENTIONAL
Conditions
Summary
The goal of the present study is to investigate effects of progressive resistance training on central nervous system functioning (corticospinal excitability (CSE)) and walking capacity in persons with multiple sclerosis (pwMS). A total of 54 pwMS will be enrolled and randomized into 1 of 3 groups: high dose resistant training (RT), low dose RT, and waitlist control.
Eligibility
Inclusion Criteria4
- Age ≥ 18 years
- MS diagnosis according to the McDonald diagnostic criteria
- Shows impairments in walking capacity
- Ability to self transport to test and exercise
Exclusion Criteria6
- Pregnancy
- Neurological or other comorbidities that affects the nervous system
- Relapse within the past 2 months
- Pacemaker or metallic implants
- Hypertension (medically unregulated)
- Participation in structured RT over the past 3 months (≥ 2 sessions/week).
Interventions
The RT exercise regime will focus on lower extremity exercises (60-90% of 1 repetition maximum) as well as incorporating functional exercises.
Locations(2)
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NCT06374108