Prospective Cohort Study of Complications and Outcomes in Cirrhosis
The Complications and Outcomes of Acutely Decompensated Cirrhosis: a Multi-center Nested Cohort Study
Nanfang Hospital, Southern Medical University
660 participants
Jan 1, 2024
OBSERVATIONAL
Conditions
Summary
This is a multi-center, nested cohort study intended to investigate the prevalence, risk factors, and outcomes of complications in patients with acutely decompensated cirrhosis, especially focused on Cytomegalovirus (CMV) reactivation, bacterial infections, hepatic encephalopathy, and Hepatorenal syndrome. Patients diagnosed with acutely decompensated cirrhosis were enrolled. Upon enrollment, detailed baseline data were collected and samples were harvested. Complications were assessed during hospitalization. Post-discharge follow-up was conducted through telephonic interviews at Day 30 and Day 90.
Eligibility
Inclusion Criteria4
- Informed written consent
- Age between 18 years and 80 years
- Cirrhosis based on liver histology or a combination of characteristic clinical, biochemical, and imaging features
- Complications of decompensated cirrhosis (ascites, gastrointestinal bleeding and hepatic encephalopathy)
Exclusion Criteria4
- Malignancy
- Acquired immune deficiency syndrome
- Received immunosuppressive drugs for non-hepatic reasons
- Received organ transplantations
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Interventions
All enrolled patients are monitored for CMV reactivation and hepatic encephalopathy using regular clinical tests or library test
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06374511