RecruitingPhase 4NCT06380491

Melatonin's Effect on Nighttime Blood Pressure and Sleep in OSA Patients (MEBP-OSA)

Impact of Melatonin Treatment on Blood Pressure Circadian Rhythm, Sleep and Metabolic Variables.

Sponsor

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Enrollment

50 participants

Start Date

Jun 22, 2023

Study Type

INTERVENTIONAL

Conditions

Obstructive Sleep Apnea of Adult

Summary

The goal of this clinical trial is to learn if melatonin works to treat comorbid insomnia in adults with OSA and nocturnal non-dipping blood pressure pattern. The main question it aims to answer is: Does melatonin maintain sleep during night and recover the dipping blood pressure pattern?

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria2

Polisomnographic diagnosis of Obstructive Sleep Apnea
Non-dipping blood pressure on Ambulatory blood pressure monitoring (ABPM):

Exclusion Criteria3

Use of sleep or psychiatric medication
Use of Positive Airway Pressure (CPAP or Bipap)
Neurologic or psychiatric disorder

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Interventions

DRUGMelatonin 3 MG Oral Tablet

Participants with OSA and nocturnal non-dipping Blood Pressure will be randomly assigned to a treatment with melatonin 3mg/d or to receive only the usual care.