Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors

This early-phase study tests a new experimental drug called ACE-86225106 in patients with advanced solid tumors (cancers in organs or tissues) that have not responded to standard treatments. The study aims to find the right dose and assess safety. **You may be eligible if...** - You are 18 or older (in most cases) - You have an advanced solid tumor that is hard to treat or that you cannot tolerate standard treatments for - You are in good general health (ECOG 0-1) - Your cancer can be measured on scans - Your expected survival is at least 3 months - You are able to provide tumor tissue and blood samples for genetic testing **You may NOT be eligible if...** - You recently received anti-cancer drugs, major surgery, or radiation - Your organ function is inadequate - You have certain other cancers or serious medical conditions Talk to your doctor to see if this trial is right for you.