Head and Neck Carcinoma Clinical Research Platform for Molecular and Blood-based Biomarkers, Treatment and Outcome

This is a research database (registry) study that collects blood samples and tumor tissue from patients with squamous cell carcinoma of the head and neck who are receiving palliative (non-curative) treatment. Researchers will use these samples to look for biological markers that might predict treatment outcomes. **You may be eligible if...** - You are 18 or older - You have confirmed squamous cell carcinoma of the head and neck (mouth, throat, voice box, or lower throat) - You are receiving palliative systemic treatment or best supportive care (curative treatment is not an option) - You consent within 4 weeks of starting first-line palliative treatment (or within 6 weeks of diagnosis if receiving supportive care only) **You may NOT be eligible if...** - There are no exclusion criteria listed for this study Talk to your doctor to see if this trial is right for you.