The PRO-FUTURE Project
PRecocious biOmarkers oF Unilateral ureTero-pelvic jUnction obstRuction in childrEn
University of Campania Luigi Vanvitelli
85 participants
Jan 30, 2024
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to learn about specific biomarkers of unilateral ureteropelvic junction obstruction (UPJO) in children undergoing surgical intervention for unilateral UPJO compared with controls. The main question it aims to answer are: * Are Urinary single-cell and extracellular vesicles (EVs) screening useful to stage the intrarenal injury and repair processes in UPJO babies? * Do babies with unilateral UPJO have a whole blood gene expression profiling (WBGEP) allowing an accurate unilateral UPJO diagnosis?
Eligibility
Inclusion Criteria2
- unilateral UPJO
- years of age
Exclusion Criteria5
- bilateral UPJO
- previous surgical intervention on the urinary tract
- bladder or lower urinary tract symptoms or malformations
- nephro- or urolithiasis, vesicoureteral reflux
- urinary tract infections.
Interventions
Urinary single-cell and EVs screening to stage the intrarenal injury and repair processes in UPJO babies and identification of the whole blood gene expression profiling of babies with unilateral UPJO. Data deriving from patients with unilateral UPJO will be compared with data deriving from controls.
Locations(5)
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NCT06382233