Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation
The Effect of Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following Distal Radius Fracture Fixation: a Randomized Controlled Trial - The TRADR Study
University Health Network, Toronto
90 participants
Aug 13, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people undergoing surgery for a wrist fracture compared to not using topical TXA (placebo).
Eligibility
Inclusion Criteria4
- Patients undergoing open reduction internal fixation (Volar approach) for operative management of a distal radius fracture;
- Aged 18 or older;
- Provision of informed consent;
- Cognitive ability and English-language skills required to complete outcome measures.
Exclusion Criteria11
- Revision surgery or any additional operative management of ipsilateral wrist injury
- Distal radius fracture treated with a dorsal approach
- Known history of lymphedema or lymph node dissection in the operative extremity
- Known chronic pain conditions, fibromyalgia, or polymyalgia rheumatic
- Current user of opioids and/or on chronic opioids use
- Known allergic reaction to TXA
- Anticoagulant use not stopped in time for surgery as per thrombosis Canada guidelines (i.e. warfarin, acetylsalicylic acid, direct oral anticoagulants, etc.)
- Previous thrombotic stroke or thromboembolic disorders (i.e. known previous DVT, PE, or clotting disorders)
- Current pregnancy or breastfeeding
- Previous neurologic injury causing paralysis of affected shoulder/arm
- Severe cardio-respiratory disease (i.e. ASA Grade IV or higher).
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Interventions
10mL of 100mg/mL TXA will be administered into the surgical wound prior closure.
10mL of 100mg/mL normal saline will be administered into the surgical wound prior closure.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06384456