Prednisone for CRPS in Distal Radius Fracture
Prednisone for the Early Treatment of Complex Regional Pain Syndrome After Distal Radius Fracture - a Pilot Randomized Trial
University of British Columbia
40 participants
Oct 10, 2024
INTERVENTIONAL
Conditions
Summary
Wrist fractures are the most prevalent adult fracture. Complex regional pain syndrome (CRPS) is a common complication that can occur, leading to permanent disability and is costly to the patient and healthcare system. In addition, amidst the opioid epidemic, the risk of increased opioid use in patients with CRPS prompts the need to find viable treatment strategies. This study aims to evaluate an anti-inflammatory medication, prednisone, in the early treatment of CRPS. Patients with wrist fractures who undergo surgical treatment will be randomized to receiving placebo vs prednisone for 2 weeks. Clinical assessments in the follow up period will be compared.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
40 mg PO once daily for 14 days starting day of surgery
Placebo tablet (cellulose) PO once daily for 14 days starting day of surgery
Locations(1)
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NCT06453447