RecruitingNot ApplicableNCT06385106

Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease

Effects of Repetitive Transcranial Magnetic Stimulation on Sleep and Cognitive Function in Patients With Alzheimer's Disease: a Randomized, Double-blind, Controlled Study


Sponsor

First Affiliated Hospital of Zhejiang University

Enrollment

30 participants

Start Date

Mar 16, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Previous studies have shown that repetitive transcranial magnetic stimulation (rTMS) can improve cognitive function in Alzheimer's disease (AD), but studies on the improvement of sleep disorders in AD are limited. The aim of this study was to evaluate the effects of rTMS on sleep and cognition in patients with mild-to-moderate Alzheimer's disease (AD).


Eligibility

Min Age: 55 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing repetitive transcranial magnetic stimulation (rTMS) — a non-invasive brain stimulation technique using magnetic pulses — to improve memory and thinking in people with Alzheimer's disease. **You may be eligible if...** - You are between 55 and 80 years old - You have confirmed Alzheimer's disease based on brain scans or spinal fluid testing - You have mild-to-moderate memory impairment (MMSE score 10–27) - You have no significant vision or hearing problems - If you are on Alzheimer's medications, your dosage has been stable for at least 3 months **You may NOT be eligible if...** - You have a history of epilepsy or seizures - You have had a stroke or brain surgery - You have metal implants or a pacemaker - You have severe liver, kidney, or lung disease - You have taken sedatives like barbiturates or benzodiazepines within the past 2 weeks Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEReal repetitive transcranial magnetic stimulation

The target brain region for stimulation was the left dorsolateral prefrontal lobe. The intensity of the stimulation was 80% of the resting motor threshold (MT) of each subject. In the target brain region, we applied 40 stimuli at a frequency of 20 Hz and the MT for 1600 pulses per session.

DEVICESham repetitive transcranial magnetic stimulation

The target brain region for stimulation was the left dorsolateral prefrontal lobe. The intensity of the stimulation was 80% of the resting motor threshold (MT) of each subject. In the target brain region, we applied 40 stimuli at a frequency of 20 Hz and the MT for 1600 pulses per session. The patients were applied with the coil angled away from the head to reproduce the noise of the stimulation as well as some local sensation


Locations(1)

The First Affiliated Hospital of Zhejiang University

Hangzhou, Zhejiang, China

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NCT06385106


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