A Novel Individualized Connectome-guided Approach for Precision Intermittent Theta Burst Stimulation for Depression

This study is testing a personalized, brain-scan-guided brain stimulation treatment called Intermittent Theta Burst Stimulation (iTBS) — a form of transcranial magnetic stimulation — for people with depression that has not responded well to antidepressants. **You may be eligible if...** - You are 21 or older - You have been diagnosed with a Major Depressive Episode (DSM-5 criteria) - Your depression score is 20 or above on a standard rating scale - You have tried at least one antidepressant for at least 4 weeks without adequate benefit **You may NOT be eligible if...** - You have a psychotic disorder - You have drug or alcohol dependence in the past 3 months - You are at high risk of suicide requiring urgent treatment - You have epilepsy or significant neurological disease - You have a pacemaker, cochlear implant, or metal in your skull - You are pregnant or cannot undergo an MRI Talk to your doctor to see if this trial is right for you.