Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway

This study tests whether certain markers in the blood can help identify lung cancer early in people who are heavy smokers and also have artery disease (blockages in blood vessels). Early detection through blood tests could allow treatment when the cancer is most curable. **You may be eligible if...** - You are between 45 and 75 years old (or up to 80 by some criteria) - You are a current or former smoker with at least 10 years of daily smoking - You have artery disease (heart, legs, or other vessels), a high coronary calcium score, or qualify for lung cancer screening based on smoking history - You are in medical follow-up for a smoking-related condition **You may NOT be eligible if...** - You have been diagnosed with cancer in the last 5 years (with some exceptions) - You have symptoms suggesting lung cancer (unexplained weight loss over 7 kg, or coughing up blood) - You have known lung nodules requiring specialist monitoring - You have pulmonary fibrosis or pulmonary hypertension - You have severe heart or breathing problems at rest - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.