Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway

Inclusion Criteria24

• All PREVALUNG or PREVALUNG ETOILE participants
• Active or former smokers who have smoked daily for at least 10 years and have either atheromatous disease (coronary, lower limb, supra-aortic trunk, aortic, visceral or upper limb arteries) or a moderate or high coronary calcium score\*, \*\*.
• Age 45- 75 years and
• Medical follow-up for smoking-related atheromatous pathology and
• daily smoking for at least 10 years prior to disease (for smoking, there are no quantitative criteria or withdrawal times)
• visual coronary calcium score quantified by a radiologist on a chest CT scan.
• Age 45- 75 and
• Medical follow-up for a smoking-related pathology:
• chronic obstructive pulmonary disease / emphysema, or
• history of non-progressive cancer \> 5 years, including ENT, lung, breast, cervix, excreto-urinary tract, bladder, esophagus, stomach, pancreas, liver, kidney, chronic myeloid leukemia.
• and
• \- daily smoking for at least 10 years prior to the disease (for smoking, there are no quantitative criteria or withdrawal periods).
• Or
• Age 55 - 74
• Cumulative smoking ≥ 30 pack-years
• active or weaned for less than 15 years Or
• Age 50-75
• Smoking :
• \> 15 cigarettes /D for more than 25 years or
• \> 10 cigarettes /D for more than 30 years
• active smoking or cessation \< 10 years Or
• American recommendations :
• Age 50 - 80
• Smoking ≥20 PA