RecruitingNot ApplicableNCT06391814

Donor-Derived EBV-Specific T Cells for Life Threatening EBV-lymphoma (OLIP-EBV-TCL-01-HMR01)

Open-Label Individual Patient Study of Epstein-Barr Virus (EBV) Specific T-Cell Lines for the Treatment of a Lymphoproliferative Disease and Hemophagocytic Syndrome Associated With EBV

Sponsor

Ciusss de L'Est de l'Île de Montréal

Enrollment

1 participants

Start Date

Jan 16, 2024

Study Type

INTERVENTIONAL

Conditions

EBV Associated Lymphoma

Summary

Single-patient trial aiming to provide immunological consolidation following allogeneic stem cell transplantation to a young adult patient suffering from a systemic EBV-positive lymphoma of childhood.

Eligibility

Sex: FEMALE

Plain Language Summary

Simplified for easier understanding

This study is testing a therapy using immune cells from a donor — specifically T cells that target a virus called Epstein-Barr virus (EBV) — to treat life-threatening EBV-related lymphoma (a type of cancer) that develops in transplant recipients. **You may be eligible if...** - You are 18 or older - You are able to provide informed consent - You are not pregnant (confirmed by a pregnancy test) **You may NOT be eligible if...** - You have received certain immune-suppressing antibodies (such as ATG or Campath) within the past 28 days - You are pregnant - You have active, uncontrolled graft-versus-host disease (GVHD) — a complication of transplant where donor cells attack the recipient's body - You have any condition that could make participation unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALEBV-specific T cells

Consolidative cellular immunotherapy consisting of one (or up to 4) infusion of ex vivo expanded T cells

Locations(1)

Ciusss-Emtl

Montreal, Quebec, Canada

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NCT06391814

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