Unrelated Cord Blood Transplantation for EBV-associated Lymphoproliferative Disorders

This study tests unrelated cord blood transplantation (using stem cells from a donated umbilical cord) as a treatment for EBV-associated lymphoproliferative disorders — serious immune and blood conditions triggered by the Epstein-Barr virus (the same virus that causes mono), including chronic active EBV infection, EBV-related hemophagocytic lymphohistiocytosis (HLH), and EBV-associated lymphoma. **You may be eligible if...** - You are between 14 and 80 years old - You have been diagnosed with a confirmed EBV-associated lymphoproliferative disorder (chronic active EBV, EBV-HLH, or EBV-associated lymphoma) - Your overall health is adequate (ECOG 0–2 or equivalent for children) - Your expected survival is at least 3 months - You or your legal guardian can provide informed consent **You may NOT be eligible if...** - You do not meet the specific diagnostic criteria for the condition (as defined by current guidelines) - Your overall health is too poor for a transplant procedure Talk to your doctor to see if this trial is right for you.