RecruitingNCT06392997

Evaluation of Salivary RNA in Subjects Scheduled for Surgery for a Gynecologic Pathology


Sponsor

ZIWIG

Enrollment

2,500 participants

Start Date

Dec 5, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

GynRAN is an international, multicentre, transversal, diagnostic and non-interventional study carried out in gynecology-obstetrics/gynecological oncology departments that aims to identify a diagnostic signature for gynecological pathologies by analyzing of coding and non-coding RNA contained in patients saliva. The study population consists of patients with clinically symptomatic females with one or more of the gynecological pathologies (endometriosis, adenomyosis, ovarian cysts, fibroids, ovarian/cervical/uterine cancer) and asymptomatic females. The patients concerned by the study will be managed without modification of the care pathway, nor modification of the therapeutic indications, nor modification of the diagnostic or follow-up examinations necessary according to the context, which are carried out according to the local recommendations.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating whether RNA found in saliva can serve as a reliable marker for detecting gynecological conditions — including endometriosis, ovarian cysts, fibroids, and gynecological cancers — before or after surgery. A saliva-based test would be a much less invasive way to detect these conditions. **You may be eligible if...** - You are 18 or older - You are scheduled for surgery or a biopsy for a gynecological condition such as endometriosis, fibroids, ovarian cysts, or gynecological cancer - OR you are having a routine pap smear or cervical cancer screening **You may NOT be eligible if...** - You have had a recent bacterial or viral infection (within the past month) - You have active oral disease or an oral fungal infection - You are pregnant - You have another active non-gynecological pelvic condition - You have a known breast cancer diagnosis Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTSaliva sample

Saliva sample


Locations(13)

CHU d'Angers

Angers, France

Clinique Tivoli Ducos - IFEMENDO

Bordeaux, France

Institut Bergonié

Bordeaux, France

CHU Caen

Caen, France

CGFL

Dijon, France

CHU Lyon Sud

Lyon, France

American Hospital of Paris

Neuilly-sur-Seine, France

CHU de Rennes Site Hôpital Sud

Rennes, France

Clinique La sagesse

Rennes, France

CHU Rouen

Rouen, France

Clinique Pasteur

Toulouse, France

CHU Bretonneau-Tours

Tours, France

Institut Gustave Roussy

Villejuif, France

View Full Details on ClinicalTrials.gov

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NCT06392997


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