Platelet-rich Plasma Intradermal Injection Combined With 308 nm Excimer Light for Treating Stable Acral Vitiligo
Platelet-rich Plasma Intradermal Injection in Addition to 308 nm Excimer Light in the Treatment of Stable Acral Vitiligo: A Prospective Randomized Placebo-controlled Study
Yijian Zhu
20 participants
Feb 22, 2023
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to learn if platelet-rich plasma (PRP) works to treat acral stable vitiligo in adults. It will also learn about the safety of platelet-rich plasma. The main questions it aims to answer are: * Does PRP combined with 308 nm excimer phototherapy improve the efficacy compared to 308 nm excimer light alone in the treatment of vitiligo of the extremities? * What medical problems do participants have when taking PRP intradermal injections? Researchers will compare PRP to a placebo (a look-alike substance that contains no drug) to see if PRP works to treat acral vitiligo. Participants will: * Receive PRP intradermal injections once a month and 308 nm excimer phototherapy twice a week, or the same frequency of saline injections and phototherapy for 6 consecutive months * Visit the clinic once every 1 month for evaluations * Keep a diary of their symptoms or side effects during follow-up
Eligibility
Inclusion Criteria5
- Patients with non-segmental vitiligo stable for more than half a year;
- At least 1 separate stable lesion on each of the dorsum of the right and left hands, proximal fingers, distal fingers and palms;
- The area of white spots is less than 10 % of the total body surface area and more than 1 % of the total body surface area;
- Those who have not received systemic treatment of vitiligo and phototherapy or related treatments within 1 month ≥ 1 year without significant efficacy;
- Voluntary signing of informed consent.
Exclusion Criteria9
- Pregnant and lactating women;
- Those who have used glucocorticoids or other immunosuppressants in the last 3 months;
- Suffering from haematological disorders such as coagulation abnormalities and thrombocytopoietic disorders;
- Those who are allergic to ultraviolet light and photosensitive treatment;
- Scar constitution;
- Those with current or previous history of skin cancer or family history of skin cancer;
- Those with infectious diseases such as HIV, syphilis, hepatitis B or C;
- Those with other serious systemic diseases;
- Patients who, in the judgement of the investigator, are not suitable for inclusion in this trial.
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Interventions
PRP+308nm
NS+308nm
Locations(1)
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NCT06394349