RecruitingPhase 2NCT06398405

A Phase II Clinical Study of Epigallocatechin-3-gallate in Patients With Esophageal Squamous Cancer

Efficacy and Safety of Epigallocatechin-3-gallate, an Important Polyphenolic That Originates From Tea, in Patients With Esophageal Squamous Cancer: A Phase II Trial


Sponsor

Shandong Cancer Hospital and Institute

Enrollment

72 participants

Start Date

Apr 22, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The investigators conduct this phase II study to evaluate safety and effectiveness of EGCG in patients with dysphagia. Swallowing-related dysphagia and pain scores were recorded using the numerical rating scale (NRS) daily . Barium meal radiography was utilized to measure the luminal size and the length of the lesion area both before and after a week of EGCG treatment. The scales are translated into Chinese and guides in Chinese are developed instructing how to use the scales and perform the assessments.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This Phase II study tests EGCG (epigallocatechin-3-gallate) — a natural compound found in green tea — as a treatment to help slow or prevent progression of esophageal cancer or precancerous lesions in the esophagus (food pipe). **You may be eligible if...** - You have been diagnosed with esophageal cancer or a precancerous condition of the esophagus - You are in a stable condition appropriate for the study intervention - You are at least 18 years old with adequate organ function - You are not currently receiving chemotherapy or radiation for this condition **You may NOT be eligible if...** - You have severe esophageal bleeding or obstruction - You have significant liver disease (EGCG is processed by the liver) - You are pregnant or breastfeeding - You have allergies to green tea or its components Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHEREpigallocatechin-3-gallate

Epigallocatechin-3-gallate is administered in a solution with a concentration of 4400 umol/L


Locations(1)

Shandong Cancer Hospital

Jinan, Shandong, China

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NCT06398405


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