Mindfulness Engaged Neurostimulation for Depression

This study is testing whether combining mindfulness-based therapy with transcranial magnetic stimulation (TMS — a non-invasive brain stimulation technique) can help people with treatment-resistant depression. It targets people who haven't responded well to antidepressant medications. **You may be eligible if...** - You have been diagnosed with major depressive disorder (not bipolar) - At least one antidepressant medication has not worked for you - Your depression is rated moderate to severe on a standard scale - You have not started or changed antidepressants in the last 4 weeks **You may NOT be eligible if...** - You have a neurological condition or history of seizures - You are medically unstable - You are currently showing active suicidal behavior - You are pregnant or breastfeeding - You have a psychotic disorder or active psychotic symptoms - You have a metal implant in your head or another device that is unsafe for TMS - You cannot have an MRI scan Talk to your doctor to see if this trial is right for you.