Individualized ANH for Non-cardiac Surgery
Individualized Acute Normovolemic Hemodilution for Non-cardiac Surgery With Anticipated High-dose Red Cells Transfusion
West China Hospital
40 participants
Jun 1, 2024
INTERVENTIONAL
Conditions
Summary
In this trial, we proposed an individualized acute normovolemic hemodilution (ANH), and conduct a randomized controlled trial to testify the effect of individualized ANH on red cells requirement for non-cardiac surgeries with anticipating major blood loss in adults.
Eligibility
Inclusion Criteria3
- Patients undergoing elective non-cardiac surgery with an anticipated red blood cells transfusion \>8 units (or 1600ml)
- Aged 18\~75 years
- Preoperative Hb level \> 120g/L for men and \> 110g/L for women.
Exclusion Criteria6
- Refusal of blood transfusion
- Cardiopulmonary insufficiency
- Cerebrovascular disease
- Renal impairment
- Hemoglobinopathies or blood system diseases
- Other situations not suitable for inclusion in clinical trial.
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Interventions
Participants will undergo individualized ANH based on the West China Liu's Score after anesthetic induction. The decision of autologous blood transfusion or allogeneic red cell transfusion will be made according to the West China Liu's Score.
Locations(1)
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NCT06399536