RecruitingNCT06405334

Kinematic and Neural Dynamics of Postural Instability in Parkinson's Disease


Sponsor

VA Office of Research and Development

Enrollment

100 participants

Start Date

Nov 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Balance problems and falls are among the most common complaints in Veterans with Parkinson's Disease (PD), but there are no effective treatments and the ability to measure balance and falls remains quite poor. This study uses wearable sensors to measure balance and uses deep brain stimulation electrodes to measure electric signals from the brain in Veterans with PD. The investigators hope to use this data to better understand the brain pathways underlying balance problems in PD so that new treatments to improve balance and reduce falls in Veterans with PD can be designed.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is examining the movement patterns and brain activity that contribute to balance and posture problems in veterans with Parkinson's disease. The goal is to better understand what causes falls and unsteadiness and to explore how deep brain stimulation (DBS) affects these problems. **You may be eligible if...** - You are a veteran with a clinical diagnosis of Parkinson's disease - Your disease is at Hoehn and Yahr stage 2 or 3 (moderate, but you are still physically independent) - You are able to give informed consent (capacity assessed using a brief standardized tool) - For a sub-study: you also have a specific DBS device (STN DBS with a Percept unit) implanted **You may NOT be eligible if...** - You have dementia that significantly affects your ability to make healthcare decisions - You have another form of parkinsonism (such as PSP or CBGD) — not standard Parkinson's disease - Your disease is past stage 3 (you need assistance walking) - You have symptomatic low blood pressure when standing Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Minneapolis VA Health Care System, Minneapolis, MN

Minneapolis, Minnesota, United States

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NCT06405334


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