RecruitingNot ApplicableNCT06405750

Left Atrial Appendage Arrhythmogenic and Thrombogenic Substrate


Sponsor

University Hospital Bispebjerg and Frederiksberg

Enrollment

1,000 participants

Start Date

Aug 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of the project is to elucidate whether it is possible to identify which patients are at risk of forming blood clots that can cause stroke based on analysis of the electrocardiogram. In connection with the operation, the small pouch known as the auricle of the heart is closed, which can be completely removed after closing. This procedure is common in patients with atrial fibrillation to protect the brain from stroke. In the project, all patients will have this auricle closed if they agree to participate in the project. After closure, the auricle is usually discarded. We will analyze the blood and the auricle tissue taken (if available) in connection with the operation itself, together with the analysis of the electrocardiogram recorded before the planned heart operation.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study collects heart tissue and electrical activity data from the left atrial appendage (a small pouch in the upper left chamber of the heart) in patients undergoing open-heart surgery. The goal is to better understand why this area is prone to causing abnormal heart rhythms (arrhythmias) and blood clots. **You may be eligible if...** - You have signed an informed consent form - You are scheduled for any open-heart surgery, including bypass surgery (CABG), heart valve repair or replacement, aortic surgery, or a combination of these **You may NOT be eligible if...** - You currently have an active heart infection (endocarditis) - Follow-up is not possible for you Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREleft atrial appendage closure

systematic closure of the left atrial appendage in addition to the planned heart surgery


Locations(1)

Rigshospitalet

Copenhagen, Denmark

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NCT06405750


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