Collection of Primary Human
Collection of Primary Human Nasal Epithelial Cells
University Hospital, Tours
100 participants
Dec 6, 2024
INTERVENTIONAL
Conditions
Summary
Treatment and prevention of respiratory infections are of great interest in many medical areas. Create a physical device covered by primary human nasal cells could be very usefull in order to analyse delivery and efficiency of drugs. In this context the aim of this project is to create a collection of primary cells from the human nasal epithelium. This collection will be realised during programmed surgery, thanks to a specific device dedicated to collect nasal cells. Then the cells will be sent to the lab in order to grow at the air-liquid interface, which is an excellent 'ex vivo' model for their study.
Eligibility
Inclusion Criteria4
- Adult patients (age > 18 years) whose native language is French, or who understands French.
- Affiliation with a French social security system (CMU accepted).
- Informed consent, written and signed by the participant.
- Planned rhinological surgery (meatotomy, septoplasty or turbinoplasty for example, but other surgeries as well)
Exclusion Criteria3
- Patients under court protection, guardianship or curatorship.
- Pregnant or breast-feeding women (positive pregnancy test for women of childbearing age).
- Patients presenting a major alteration of the mucosa or a malignant rhinosinus pathology.
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Interventions
During programmed surgery (meatotomy, septoplasty or turbinoplasty for example, or other programmed surgeries), the surgeon will take an atraumatic sample from the nasal cavity using a dedicated device (brush) from the healthy nasal mucosa.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06407102