ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression

This clinical trial tests a computerized cognitive training program in people with major depression. The goal is to see whether improving thinking and memory skills (which are often affected by depression) can lead to better overall treatment outcomes for depression. **You may be eligible if...** - You are 18 to 60 years old - You have a current diagnosis of major depressive disorder (MDD), confirmed through an interview - You are fluent and literate in English - You are not experiencing psychosis **You may NOT be eligible if...** - You have bipolar disorder or another condition that explains your depression symptoms - You have a severe substance use disorder - You are currently taking certain other medications that might interfere with the study - You have neurological conditions affecting cognitive function Talk to your doctor to see if this trial is right for you.