RecruitingNCT06408961

EVOC - EVs in Obesity and Cardiometabolic Disease

Extracellular Vesicle Signaling in Obesity and Cardiometabolic Disease (EVOC)

Sponsor

Massachusetts General Hospital

Enrollment

100 participants

Start Date

Feb 2, 2019

Study Type

OBSERVATIONAL

Conditions

Cardiovascular Diseases

Summary

The goal of this observational study is to research the impact of molecular signals from the heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II Diabetes and diseases that affect the heart, blood vessels and metabolism (Cardiometabolic Disease). Specifically, the focus is on the content and function of Extracellular Vesicles (EVs), small sacs released from a cell's surface that contain important molecular cargo. The main questions it aims to answer are: 1. What molecular cargo do adipose-tissue EVs carry? 2. How do these cargo impact cardiac and hepatic function? 3. Are changes in EV content related to cardiac function and adiposity with weight loss? Tissue samples from fat tissue and blood samples will be collected from patients receiving bariatric weight loss surgery.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates tiny particles called extracellular vesicles (EVs) — microscopic signals released by cells — in people with obesity and related metabolic conditions such as prediabetes and diabetes. The goal is to understand how these particles relate to heart and metabolic disease risk. **You may be eligible if...** - You are 18 or older - You have a BMI of 30 or higher (obese category) - Some participants will also need to have prediabetes or diabetes (HbA1c above 5.7% or fasting glucose above 100 mg/dL) **You may NOT be eligible if...** - You are pregnant - You have a history of heart attack or heart valve disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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