Mood and Decision-making in Methamphetamine Use Disorder
Modulating Explore-exploit Biases by Improving Mood in Adults With Methamphetamine Use Disorder
Laureate Institute for Brain Research, Inc.
80 participants
Jul 26, 2024
INTERVENTIONAL
Conditions
Summary
In this project, the investigators examine behavior and associated brain activity during explore-exploit decision-making tasks performed pre- and post-modulation of affective state using autobiographical memory recall. The investigators hypothesize that a positive memory recall will reduce negative affective state, reduce explore-exploit biases and normalize the associated brain activity. The investigators propose a randomized double-blind, sham-controlled trial of positive autobiographical memory recall with 80 adults (n=40 per arm) with methamphetamine use disorder (MUD) currently involved in abstinence only treatment centers.
Eligibility
Inclusion Criteria4
- Adults 18-65 years old
- English proficiency as evaluated by language ability during screening
- Past-year diagnosis of DSM-5 methamphetamine use disorder (MUD) confirmed by the MINI
- Actively enrolled in treatment for substance use disorder.
Exclusion Criteria7
- Severe traumatic brain injury (as indicated by a score ≥3 on the Tulsa Head Injury Screen
- Any medical condition interfering with the participation in the study as determined by medical screening
- DSM-5 diagnosis of psychotic disorders, bipolar I disorder, or major depressive disorder with psychosis
- fMRI contraindications as listed on the MR environment screening form
- Positive breathalyzer for alcohol
- Positive urine drug screening, except for cannabis or prescribed benzodiazepines, as indicated in the medical screening
- Evidence of inability to comply with study procedures based on judgement of the experimenter.
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Interventions
Autobiographical memory recall designed to modulate mood and affective state by reminiscing about personal life events
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06410196