RecruitingPhase 2NCT06411210

Obesity Complicating Type 1 Diabetes: GLP-1 Analogue Anti-obesity Treatment

Obesity Complicating Type 1 Diabetes in Young Adults: Physiology and Impact of GLP-1 Analogue Anti-obesity Treatment on Cardiometabolic Risk Factors

Sponsor

Yale University

Enrollment

54 participants

Start Date

Jul 16, 2024

Study Type

INTERVENTIONAL

Conditions

Obesity Diabetes type1

Summary

More than 40% of young adults with type 1 diabetes (T1D) also have overweight or obesity. Each of these diagnoses increase the risk of adverse cardiovascular events. GLP-1 analogues are anti-obesity medications that are cardioprotective in adults with type 2 diabetes, however evaluation of these agents in people with T1D has been limited to glycemic outcomes. Investigators aim to study the impact of GLP-1 analogue obesity treatment on markers of cardiometabolic risk in young adults with T1D and obesity.

Eligibility

Min Age: 18 YearsMax Age: 30 Years

Plain Language Summary

Simplified for easier understanding

This study tests a GLP-1 weight-loss medication (the same class as Ozempic) in young adults aged 18–30 who have both type 1 diabetes and obesity. Managing weight is especially difficult with type 1 diabetes, and this trial explores whether anti-obesity drugs can help safely. **You may be eligible if...** - You are between 18 and 30 years old with type 1 diabetes - Your BMI is 30 or higher, or 27 or higher with a weight-related health problem - You were diagnosed with type 1 diabetes at least 12 months ago - Your HbA1c (average blood sugar level) is 10% or below - Your insulin dosing and weight have been stable for the past 3 months - You use a continuous glucose monitor **You may NOT be eligible if...** - You have type 2 diabetes - Your blood sugar or insulin dose has been unstable recently - You are pregnant, planning to become pregnant, or not using contraception Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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