RecruitingPhase 1NCT06414096

Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome


Sponsor

University of Colorado, Denver

Enrollment

5 participants

Start Date

Oct 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Hypothesis: The investigators hypothesize that pulsatile FSH intravenous administration to women with obesity will correct the Reprometabolic Syndrome (RMS) luteal deficiency phenotype. Specific Aim: To test the hypothesis that pulsatile IV administration of FSH will rescue the impaired folliculogenesis and relative hypogonadotropic hypogonadism, characteristic of obesity. The investigators will accomplish this by administering a cycle of pulsatile FSH to women with obesity and comparing their hormone output to a cycle using conventional, daily FSH injection at the identical daily dose. The primary outcome will be luteal phase progesterone excretion.


Eligibility

Sex: FEMALEMin Age: 19 YearsMax Age: 37 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Follicle Stimulating Hormone for people with infertility and obesity. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGFollicle Stimulating Hormone

Pulsatile FSH administration via a portable pump.


Locations(1)

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

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NCT06414096


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