Reduction of Mitral Regurgitation With the SATURN Trans-Septal Transcatheter Mitral Valve Replacement (TMVR) System in Patients With Severe Symptomatic Mitral Regurgitation

This study evaluates the SATURN system — a minimally invasive (catheter-based) device to replace the mitral valve in the heart without open-heart surgery — in patients with severe mitral regurgitation (a "leaky" heart valve where blood flows backward). This approach goes through a vein in the leg rather than requiring open-chest surgery. **You may be eligible if...** - You are 65 or older with severe or moderate-to-severe mitral valve leakage - Your symptoms include shortness of breath or limited activity (NYHA class II or higher) - You are considered too high-risk for traditional open-heart surgery due to age, frailty, or other health conditions - You are able to take blood thinners and complete study assessments **You may NOT be eligible if...** - Your mitral regurgitation is caused by a structural defect in the valve itself (degenerative type) - You are too frail or sick even for this less invasive procedure - You have other heart conditions that make this procedure unsafe (such as certain clots or severe aortic disease) Talk to your doctor to see if this trial is right for you.