RecruitingPhase 4NCT06414759

Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload

Sponsor

Cairo University

Enrollment

110 participants

Start Date

Jul 1, 2024

Study Type

INTERVENTIONAL

Conditions

Edema Acute Decompensated Heart Failure Volume Overload

Summary

This study aims to compare two medications, acetazolamide and metolazone, along with loop diuretics, to see which one works better and is safer for patients with ADHF who have volume overload. By comparing these medications, we hope to learn which one can help these patients the most. This will help doctors choose the best treatment for patients with ADHF and volume overload.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study tests a combination diuretic (water pill) therapy to help patients with acute decompensated heart failure (ADHF) — a sudden worsening of heart failure that causes dangerous fluid build-up in the body — eliminate excess fluid more effectively and safely. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with acute decompensated heart failure - You have clear signs of fluid overload, such as swollen legs, fluid in the abdomen, or fluid around the lungs - Your fluid overload is confirmed by clinical examination or imaging **You may NOT be eligible if...** - You have acute kidney injury at the time of admission - You have other serious conditions that would make diuretic therapy unsafe - You are outside the 18–65 age range Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAcetazolamide

Acetazolamide is a medication that belongs to the class of carbonic anhydrase inhibitors. It acts by reducing the reabsorption of sodium in the proximal tubules of the kidneys. When combined with loop diuretics, acetazolamide has the potential to enhance the effectiveness of diuretic therapy, thus aiding in the process of decongestion. It will be given 500mg orally, once daily.

DRUGMetolazone

Metolazone is a medication with properties like thiazide diuretics, prescribed for the management of congestive heart failure and hypertension. Its mechanism of action involves blocking the transport of sodium across the epithelium of renal tubules, predominantly in the distal tubules. It will be given 5mg orally, once daily.

DRUGIV Loop Diuretics

IV loop diuretic 2 times the outpatient oral (PO) daily dose, and oral loop diuretics will be stopped. In cases where the patient was not previously on oral diuretics, a starting dose of 40 mg of IV furosemide, IV bumetanide 1 mg or a bolus of 20 mg of IV torsemide can be utilized.