Clinical Evaluation of Acupuncture Treatment on Alzheimer's Disease in APOE e4 Carriers and Non-Carriers

This study is evaluating whether acupuncture can improve thinking and memory in people with Alzheimer's disease. It is also investigating whether having a particular genetic variant (APOE e4) — the strongest known genetic risk factor for Alzheimer's — affects how well someone responds to acupuncture treatment. **You may be eligible if...** - You are between 50 and 85 years old - You have been diagnosed with mild to moderate Alzheimer's disease - Your cognitive test scores fall within the range for mild to moderate Alzheimer's (based on education level) - Brain imaging (MRI) shows shrinkage in the hippocampus or medial temporal lobe consistent with Alzheimer's disease - You are willing to join voluntarily and sign consent **You may NOT be eligible if...** - Your memory problems are caused by something other than Alzheimer's (e.g., vascular dementia, thyroid problems, B12 deficiency) - You have a serious heart, liver, kidney, or blood condition - You have aphasia (difficulty speaking) or severe physical disability affecting cooperation - You have a contraindication to MRI (e.g., claustrophobia, pacemaker) - You are taking blood thinners like warfarin Talk to your doctor to see if this trial is right for you.