RecruitingPhase 4NCT06417645

Re-evaluation of the Effect Site Model of the PKPD Propofol Eleveld Model

the BIS Index Response is Poorly Described by Propofol Effect Site Eleveld's Model After Applying a Perturbation

Sponsor

Universidad del Desarrollo

Enrollment

24 participants

Start Date

Sep 1, 2013

Study Type

INTERVENTIONAL

Conditions

Surgery Healthy

Summary

in healthy patients undergoing elective surgery, after a very slow induction, using Eleveld's kinetics as a reference, after loss of consciousness (LOC) and intubation, proceed to infuse propofol until 1% burst suppression ratio is obtained. Then return to the LOC concentration. The BISindex predicted by the model and the real one will be evaluated. The evolution of spectral density frequencies over time will also be evaluated.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria1

ASA I-II patients between 18 and 60 years of age, who undergo elective surgery in the central ward of the Hospital Base San José Osorno, Chile. Consecutive patients from the beginning of the study up to 12 months from the admission of the first patient.

Exclusion Criteria4

Emergency surgery patient.
Patients with dementia, delirium or altered state of consciousness.
Full stomach or risk of aspiration.
Allergic to propofol.

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Interventions

DRUGfixed propofol infusion 15 mg/kg/h until 1% BSR (burst suppression ratio)

after a slow induction with propofol to loss of consiousness (LOC), we proceed to give remifentanil TCI and rocuronium and intubate the patient. After 5 min we infuse 15 mg/kg/h until 1%BSR observe in the BIS monitor. Then we reduce the TCI LOC predicted concentration.