Neoadjuvant Radio-chemotherapy Safety Pilot Study in Patients With Glioblastoma

This study is testing the safety of giving radiation therapy and chemotherapy before surgery (neoadjuvant treatment) for glioblastoma — the most aggressive type of brain tumor. By treating the tumor before removing it, researchers hope to make surgery more effective and improve outcomes. **You may be eligible if...** - You are between 18 and 75 years old - You have a single brain tumor (glioblastoma) confined to one area of one side of the brain (supratentorial, unifocal, unilobar) - Your tumor appears completely removable based on imaging **You may NOT be eligible if...** - Your tumor involves multiple brain regions, crosses to the other side of the brain, or affects the brain stem or cerebellum - Your tumor has caused a midline shift greater than 1 cm (a dangerous shift of brain structures) - You are experiencing symptoms of dangerously high brain pressure requiring steroid treatment - You have another active cancer - You have any condition that prevents you from having surgery, radiotherapy, or chemotherapy with temozolomide - You have significant cognitive impairment - You are a woman of childbearing potential (per specific CTFG criteria) Talk to your doctor to see if this trial is right for you.