Induction Chemoimmunotherapy Combined With Chemoradiotherapy in Esophageal Cancer

This study is testing a combination approach for locally advanced esophageal (food pipe) cancer: chemotherapy plus immunotherapy given first, followed by chemoradiation (combined chemotherapy and radiation therapy). The goal is to shrink the tumor as much as possible before or instead of surgery. **You may be eligible if...** - You are aged 18–80 with confirmed esophageal squamous cell carcinoma (a specific cancer type) - Your cancer is locally advanced but has not spread to distant organs (or only to nearby lymph nodes above the collarbone) - You are in good overall health (ECOG 0–1) with normal blood counts and organ function - You have not had prior chemotherapy or radiation for this cancer **You may NOT be eligible if...** - Your cancer has spread far beyond the esophagus - You have significant organ problems (heart, lungs, kidneys, liver) - You are pregnant or breastfeeding - You have an active autoimmune condition Talk to your doctor to see if this trial is right for you.