RecruitingNCT06421493

Role of the Maternal Microbiota on the Immune Response and Metabolism During Hypertensive Disorders

Sponsor

Istituto Clinico Humanitas

Enrollment

300 participants

Start Date

Jun 6, 2020

Study Type

OBSERVATIONAL

Conditions

Preeclampsia

Summary

Preeclampsia (PE) is a significant cause of maternal and fetal morbidity and mortality, characterized by high blood pressure and proteinuria during pregnancy. It has two main phenotypes: one linked to placental damage and the other to metabolic factors like obesity. Early identification of high-risk groups is crucial, though there's ongoing disagreement over its classification. Research suggests a potential connection between maternal gut bacteria and PE, offering avenues for improved prevention strategies. This study aims to investigate the differences in maternal gut microbiota between these two PE phenotypes.

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how the gut bacteria (microbiome) in pregnant women affect the immune system and metabolism when pregnancy is complicated by high blood pressure or poor fetal growth. The goal is to find patterns that might predict or help prevent these serious pregnancy complications. **You may be eligible if...** - You are over 18 with a single pregnancy - You are between 11–13 weeks pregnant - Your pregnancy is complicated by high blood pressure (hypertension), preeclampsia, or fetal growth restriction — OR - You are in a high-risk group based on first-trimester screening, OR - You have a low-risk, normal pregnancy (for comparison purposes) **You may NOT be eligible if...** - You are carrying multiple babies (twins or more) - You have a fetal condition not related to growth restriction - You are unable to provide consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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