RecruitingNot ApplicableNCT06424184

Accelerated rTMS for Substance Use Disorder and Depression

Substance Use Disorder Treatment With Accelerated Repetitive Transcranial Magnetic Stimulation for Depression (START-D)


Sponsor

University of Texas Southwestern Medical Center

Enrollment

40 participants

Start Date

Jun 25, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a small open-label feasibility trial of an accelerated course of repetitive transcranial magnetic stimulation (rTMS) for individuals with depression and stimulant use disorder \[including methamphetamine or cocaine use disorder (MUD/CUD)\].


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether an accelerated form of repetitive transcranial magnetic stimulation (rTMS) — a non-invasive brain stimulation technique — can help reduce stimulant use (cocaine or methamphetamine) and improve depression symptoms at the same time. **You may be eligible if...** - You are between 18 and 65 years old - You have used cocaine or methamphetamine on at least 10 days in the past month - You have a diagnosis of moderate or severe cocaine or methamphetamine use disorder - You have mild to moderate depression symptoms (PHQ9 score ≥ 5) - You can read and speak English well enough to participate **You may NOT be eligible if...** - You have heavy alcohol, benzodiazepine, or sedative use that would make participation unsafe - You have a serious medical condition or terminal illness - You have a history of seizures or a brain implant that would make brain stimulation unsafe - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEAccelerated Repetitive Transcranial Magnetic Stimulation

The rTMS protocol implemented in this study will include approximately 10-minute long sessions of intermittent theta burst stimulation (iTBS) with at least 50 minutes in between iTBS sessions. Study participants will receive the rTMS intervention for up to 50 sessions across a three-week period. The total of 50 sessions will be administered as up to 4 sessions each day, up to 5 days per week over an up to 3-week-long period.


Locations(1)

UT Southwestern Medical Center

Dallas, Texas, United States

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NCT06424184


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