RecruitingPhase 2NCT06424756

Effects of an Antioxidant Supplement on Blood Vessel Health

Role of Mitochondria-derived Oxidative Stress on Microvascular Endothelial Function in Healthy Non-Hispanic Black and White Adults

Sponsor

University of Georgia

Enrollment

60 participants

Start Date

Jul 1, 2024

Study Type

INTERVENTIONAL

Conditions

Healthy

Summary

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and the non-Hispanic Black (NHB) population is disproportionately affected. Our research has previously demonstrated that oxidative stress may contribute to reduced vascular function in otherwise healthy NHB adults, potentially predisposing them to the development of hypertension and CVD. This study is designed to examine whether the mitochondria are an important source of oxidative stress-induced vascular dysfunction in healthy NHB adults.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether an antioxidant supplement can improve blood vessel health — specifically how well blood vessels expand and contract — in healthy adults. The study is particularly interested in comparing effects between non-Hispanic Black and non-Hispanic White participants. **You may be eligible if...** - You identify as non-Hispanic Black or non-Hispanic White - You are between 18 and 75 years old - You do not have high blood pressure (BP below 130/85) - Your cholesterol (LDL) and blood sugar (HbA1c) are in a healthy range **You may NOT be eligible if...** - You smoke or have used nicotine products in the past year - You have a skin condition such as psoriasis, eczema, or vitiligo - You have kidney disease, cardiovascular disease, or diabetes - You are pregnant or breastfeeding - You take certain medications that interact with the supplement - You have a history of cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTMitoQ

MitoQ supplement is composed of mitoquinol mesylate, which is a synthetic analog of coenzyme Q10

DIETARY_SUPPLEMENTPlacebo

MitoQ matched Placebo

DRUGMitoTempo

During each experimental visit, intradermal microdialysis will be used to locally infuse MitoTempo (a mitochondria-specific superoxide dismutase mimetic) into the cutaneous microvasculature in the ventral aspect of the left forearm.

DRUGTempol

During each experimental visit, intradermal microdialysis will be used to locally infuse Tempol (a superoxide dismutase mimetic) into the cutaneous microvasculature in the ventral aspect of the left forearm.

DRUGL-NAME

During each experimental visit, L-NAME (nitric oxide synthase inhibitor) will be perfused through microdialysis fibers for quantification of nitric oxide-mediated vasodilation.

DRUGSNP - Sodium Nitroprusside

At the end of each experimental visit, SNP will be perfused through microdialysis fibers to elicit a maximal vasodilation response.