Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO)
Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation
University Hospital, Ghent
300 participants
Aug 19, 2016
INTERVENTIONAL
Conditions
Summary
Pharmacokinetics of antibiotics in critically ill neonates, infants and children on extracorporeal membrane oxygenation (ECMO).
Eligibility
Inclusion Criteria5
- patients admitted to the pediatric intensive care unit or cardiac intensive care unit
- patient age : 1,8 kg-15 years
- patient receiving antibiotic treatment (piperacillin-tazobactam, meropenem, amoxicillin-clavulanate, cephazolin, vancomycin, teicoplanin, ciprofloxacin, amikacin)
- intra-arterial or intravenous access other than the drug infusion line available for blood sampling (arterial line is preferred)
- extracorporeal membrane oxygenation circuit
Exclusion Criteria3
- no catheter in place for blood sampling
- absence of parental/patient consent
- known hypersensitivity to beta-lactam antibiotics and ciprofloxacin
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Interventions
blood sampling in patients receiving amoxicillin-clavulanate as part of routine clinical care
blood sampling in patients receiving piperacillin-tazobactam as part of routine clinical care.
blood sampling in patients receiving meropenem as part of routine clinical care.
blood sampling in patients receiving cefazolin as part of routine clinical care.
blood sampling in patients receiving vancomycin as part of routine clinical care.
blood sampling in patients receiving teicoplanin as part of routine clinical care.
blood sampling and urine sampling in patients receiving ciprofloxacin as part of routine clinical care.
blood sampling in patients receiving amikacin as part of routine clinical care.
Locations(3)
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NCT06426836