RecruitingNCT06426953
Predictive Effect of TGF-β and INS-PI3K-AKT Related Proteins for POD in Diabetes Patients
Predictive Effect of TGF-β Combined With INS-PI3K-AKT Signaling Pathway Related Proteins (ADNP, MAP6, Pgc-1α) for POD in Diabetes Patients
Sponsor
Xie Kangjie
Enrollment
180 participants
Start Date
May 20, 2024
Study Type
OBSERVATIONAL
Conditions
Summary
To investigate the relationship between POD, TGF-β and INS-PI3K-AKT signaling pathway related proteins (ADNP, MAP6, PGC-1α) in diabetic patients
Eligibility
Min Age: 65 Years
Inclusion Criteria4
- Age ≥65 years
- History of diabetes ≥2 years and Glycated hemoglobin ≥6.5% or no history of diabetes and normal blood glucose
- The ASA rating is Class I to III
- The elderly patients of limited thoracic and abdominal tumor surgery
Exclusion Criteria10
- Refused to participate
- Previous history of schizophrenia, epilepsy, Parkinson's disease
- History of alcohol abuse or drug dependence
- Patients with ASA grade IV and above
- Severe visual or hearing impairment, can not cooperate with the completion of cognitive function tests
- Participants in other clinical trials within the last two months
- Patients with severe arrhythmia or cardiac dysfunction(EF<40%)
- There was a clear history of neurological and psychiatric problems or long-term use of sedatives or antidepressants
- History of cerebrovascular disease or brain surgery or trauma
- Severe liver dysfunction (Child-Pugh class C) or severe renal dysfunction (requiring dialysis)
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Interventions
OTHERNo intervention
No intervention
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT06426953
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