The Effects of Low-Dose Versus High-Dose Intravenous IRON Therapy With Ferric DerisomaltOSE in Patients With Chronic Heart Failure and Iron Deficiency

This study is testing whether a low dose or high dose of IV iron (given through a vein) works better for people who have chronic heart failure and low iron levels. Researchers want to see which amount improves exercise ability and heart function more. **You may be eligible if...** - You are over 18 years old - You have heart failure with reduced pumping function (heart pumps less than 50% of normal) - Your symptoms are moderate — you feel breathless or tired with everyday activities but not at rest - You were hospitalized for heart failure in the past 6 months OR have had abnormal heart-related blood tests recently - Your heart failure has been stable for at least 4 weeks on your current medications - Your iron levels are low (low ferritin or low iron saturation in the blood) - You are able to do a supervised exercise breathing test **You may NOT be eligible if...** - Your blood count (hemoglobin) is very low or very high - You are on kidney dialysis or have severe kidney disease - You weigh less than 35 kg - Your heart failure was caused by a leaky or narrowed valve, or a birth defect of the heart - You have a known iron storage disease (like hemochromatosis) or a family member has it - You are allergic to IV iron products - You have an active infection, active bleeding, cancer, or a blood disorder - You had a heart attack or stroke in the past 3 months - You are pregnant or breastfeeding - You have been on IV or oral iron therapy in the last 30 days Talk to your doctor to see if this trial is right for you.