Study of Psilocybin Assisted Psychotherapy to Address Fear of Recurrence

This study is testing whether psilocybin-assisted psychotherapy can reduce fear of cancer recurrence — a common and distressing source of anxiety in cancer survivors — in women with either early-stage breast cancer (low recurrence risk) or late-stage ovarian cancer (high recurrence risk who are currently in remission). **You may be eligible if...** - You are 21 years or older - You have early-stage breast cancer (Stage 1 or 2) with less than 20% chance of recurrence at 10 years, and you completed primary treatment more than 6 months ago, OR you have Stage 3 or 4 ovarian cancer that is currently in remission, with more than 80% chance of recurrence at 10 years - You are in generally good health (ECOG 0–1) - You experience significant fear of your cancer coming back **You may NOT be eligible if...** - You have unstable medical conditions or significant heart problems (such as heart failure, serious arrhythmias, or recent heart attack) - You have congenital long QT syndrome or a prolonged QT interval on your ECG - You have a personal or family history of psychosis or schizophrenia - You currently have uncontrolled high blood pressure or serious kidney disease - You are currently taking certain psychiatric medications that could interact with psilocybin Talk to your doctor to see if this trial is right for you.