RecruitingNCT06432023

Imaging - Clinical Evaluation of Altered Nervous System Drainage

Multi-signal Analysis of the Composition and Movement of Fluid in Various Cerebral Compartments in Healthy Subjects and Subjects With White Matter Pathology

Sponsor

IRCCS Eugenio Medea

Enrollment

100 participants

Start Date

Oct 1, 2023

Study Type

OBSERVATIONAL

Conditions

Neuroinflammation Autism Spectrum Disorder

Summary

The current study aims to evaluate the aspects of perfusion, fluid diffusivity in the interstitium and the T1 and T2 signal of the PVS and WMH. The current study has the following objectives: a) evaluate the perfusion aspects using the gadolinium-based contrast medium of brain tissues in the short term; b) the direction of flow of fluids at very low speed in the white matter using the DTI sequences configured for this purpose; c) T1-mapping of the lesions of interest. The expected results will help us understand two aspects of neurofluid dynamics: a) how the fluid moves within the central nervous system in the first minutes after the injection of the tracer (in our case the gadolinium-based contrast medium) and b) what is the composition of the fluid within the PVS and WMH and how can investigators characterize them more accurately.

Eligibility

Min Age: 2 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is using specialized brain imaging (MRI with contrast dye) to better understand how waste and fluid drain from the brain in people who have changes in their brain's white matter or enlarged fluid-filled spaces (perivascular spaces), which are often linked to aging or vascular disease. **You may be eligible if...** - Your brain MRI has shown white matter changes (areas of altered signal) and/or enlarged perivascular spaces (enlarged fluid channels in the brain) **You may NOT be eligible if...** - You have an allergy or other reason you cannot receive MRI contrast dye - You are medically unstable and cannot safely undergo prolonged sedation - You have a brain tumor - You have any other condition that makes MRI unsafe for you (such as certain metal implants) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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