RecruitingNCT06437067

Study on Prognosis of Acute-on-chronic Liver Failure Complicated by Bacterial or Fungal Infection

A Real-world Study on the Long-term Prognosis of Acute-on-chronic Liver Failure


Sponsor

Qin Ning

Enrollment

400 participants

Start Date

Mar 1, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

The subjects of this study were inpatients with ACLF who were admitted to Tongji Hospital in Wuhan from March 2023 to June 2025. After patients were enrolled, The patient's general information (gender, age, past medical history, etc.), complications (ascites, hepatic encephalopathy, hepatorenal syndrome, gastrointestinal bleeding, etc.), laboratory tests (CRP, PCT, INR, WBC, fungal/bacterial diagnostic tests, etc.), symptoms and signs at the time of infection, and at admission (D1), D4, D7, D14, D21, etc.) were recorded Save the blood separately. The patients were divided into fungal infection group, bacterial infection group and non-infection group according to the infection status after admission.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria2

  • TBIL ≥ 12 mg/mL and INR ≥ 1.5
  • Chronic hepatitis B

Exclusion Criteria1

  • (1) <18 or >80 years old; (2) primary hepatic or extrahepatic carcinoma; (3) with severe diseases of other organs or systems; (4) pregnancy; (5) imcomplete information

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Locations(1)

Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

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NCT06437067


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