Acute-On-Chronic Liver Failure Clinical Trials

15 recruiting

Acute-On-Chronic Liver Failure Trials at a Glance

17 actively recruiting trials for acute-on-chronic liver failure are listed on ClinicalTrialsFinder across 6 cities in 29 countries. The largest study group is Not Applicable with 5 trials, with the heaviest enrollment activity in Guangzhou, New Delhi, and Beijing. Lead sponsors running acute-on-chronic liver failure studies include Third Affiliated Hospital, Sun Yat-Sen University, Sun Yat-sen University, and Qilu Hospital of Shandong University.

Browse acute-on-chronic liver failure trials by phase

Treatments under study

About Acute-On-Chronic Liver Failure Clinical Trials

Looking for clinical trials for Acute-On-Chronic Liver Failure? There are currently 15 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Acute-On-Chronic Liver Failure trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Acute-On-Chronic Liver Failure clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 117 of 17 trials

Recruiting
Not Applicable

COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device

SarcopeniaUltrasonographyAcute-On-Chronic Liver Failure+1 more
University Hospital, Antwerp20 enrolled1 locationNCT06079021
Recruiting
Not Applicable

Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis

SepsisAcute-On-Chronic Liver Failure
Third Affiliated Hospital, Sun Yat-Sen University192 enrolled1 locationNCT06562803
Recruiting
Not Applicable

The Effects of Double Plasma Molecular Adsorption System in Acute on Chronic Liver Failure Patients

Acute-On-Chronic Liver FailureAcute on Chronic Hepatic Failure
Chulalongkorn University40 enrolled1 locationNCT05030571
Recruiting

Analysis of Methylomic Features and Prognostic Risk Prediction in Patients With Hepatitis B-related Acute-on-chronic Liver Failure

HBV-related Liver CirrhosisHBV Related Acute-on-chronic Liver FailureHBV (Hepatitis B Virus)
Qilu Hospital of Shandong University100 enrolled1 locationNCT07275554
Recruiting

Risk Factors Affecting MSC Efficacy in ACLF Patients

Acute-On-Chronic Liver Failure
Sun Yat-sen University446 enrolled1 locationNCT07198854
Recruiting
Phase 2

F573 for Injection for the Treatment of Liver Injury/Failure

Acute-On-Chronic Liver FailureAcute Liver Failure
Beijing Continent Pharmaceutical Co, Ltd.97 enrolled10 locationsNCT05689645
Recruiting

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

Liver Transplant; ComplicationsLiver CirrhosisLiver Diseases+1 more
European Foundation for Study of Chronic Liver Failure3,000 enrolled106 locationsNCT04613921
Recruiting
Not Applicable

Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure (ACLF) Patients With Severe Coagulopathy

Acute-On-Chronic Liver Failure
Institute of Liver and Biliary Sciences, India934 enrolled1 locationNCT06831565
Recruiting
Phase 1

Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults

Acute-On-Chronic Liver FailureChronic Liver Failure
RenJi Hospital10 enrolled1 locationNCT05727722
Recruiting

Single Cell Landscape of HBV-related Acute-on-chronic Liver Failure Patients

HBV Related Acute-on-chronic Liver Failure
Qilu Hospital of Shandong University21 enrolled1 locationNCT06865859
Recruiting
Phase 1Phase 2

Efficacy and Safety of BMSCs (CG-BM1) for ACLF Patients

Acute-On-Chronic Liver Failure
Sun Yat-sen University90 enrolled1 locationNCT06740149
Recruiting

Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF

Acute-On-Chronic Liver FailureHepatitis B, Chronic
Third Affiliated Hospital, Sun Yat-Sen University200 enrolled1 locationNCT04597164
Recruiting

Long-term Prognosis of Patients With Hepatitis B Related Acute-on-chronic Liver Failure

Hepatitis BAcute-On-Chronic Liver Failure
Third Affiliated Hospital, Sun Yat-Sen University300 enrolled1 locationNCT04310787
Recruiting
Not Applicable

Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF

Hepatitis BAcute-On-Chronic Liver Failure
Third Affiliated Hospital, Sun Yat-Sen University150 enrolled1 locationNCT03920618
Recruiting

Study on Prognosis of Acute-on-chronic Liver Failure Complicated by Bacterial or Fungal Infection

Acute-On-Chronic Liver Failure
Qin Ning400 enrolled1 locationNCT06437067
Recruiting
Phase 1Phase 2

Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure

Acute-On-Chronic Liver Failure
Beijing 302 Hospital150 enrolled1 locationNCT05985863
Recruiting

Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease

SurgeryLiver CirrhosisAcute-On-Chronic Liver Failure+2 more
University Hospital, Bonn200 enrolled1 locationNCT04578301