BMI-Driven Tolerability and Efficacy of Entresto in Heart Failure Patients

This study examines how well and how safely patients with heart failure with reduced pumping function (HFrEF) tolerate Entresto (sacubitril/valsartan) depending on their body weight (BMI). Entresto is a heart medication that helps the heart pump more efficiently. **You may be eligible if...** - You are 18 or older - You have been diagnosed with heart failure with reduced ejection fraction (your heart pumps out 35% or less of blood per beat) - You have never taken Entresto before, or you are willing to switch from your current ACE inhibitor or ARB medication - You are able to provide informed consent **You may NOT be eligible if...** - You have severe kidney disease (eGFR below 30) or severe liver disease - You have a history of angioedema (severe tissue swelling, often from prior ACE inhibitor use) - You are pregnant or breastfeeding - You have active cancer or another serious medical condition - You have a history of not taking your medications as prescribed Talk to your doctor to see if this trial is right for you.