RecruitingNCT06441357

Differentiating the Invasiveness of Lung Adenocarcinoma by Dual Energy CT Parameter

Differentiating the Invasiveness of Lung Adenocarcinoma by Dual Energy CT Using Extracellular Volume Measured in Delay Phase

Sponsor

Tang-Du Hospital

Enrollment

2,000 participants

Start Date

Jun 1, 2024

Study Type

OBSERVATIONAL

Conditions

Adenocarcinoma of Lung

Summary

The core purpose of this study is to investigate whether the extracellular volume (ECV) fraction measured in delay phase by dual energy computed tomography (DECT) can distinguish precancerous lesions from early-stage lung adenocarcinomas, which could assist clinical decision making for surgery operation indication and strategy.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

patients older than 18 years old with pulmonary nodules (diameter≤3 cm).
pathologically confirmed as lung adenocarcinoma.
without history of other malignancies.
accurate hematocrit within 1 week before contrast enhanced dual energy CT examination.

Exclusion Criteria5

with a history of allergy to iodine contrast agents and other reasons who are unable to complete the examination.
without histopathology of invasion stage, such as AAH, AIS, MIA and IAC.
history of chemotherapy, radiotherapy, or other anti-tumor therapy before contrast enhanced dual energy CT.
poor image quality.
contrast enhanced dual energy CT scans ≥ 4 weeks before surgery.