RecruitingNCT06444126

The Incidence And Risk Factors Of Recurrent Febrile Seizures And Epilepsy Following Febrile Seizures

A Prospective Cohort Study Of The Incidence And Risk Factors Of Recurrent Febrile Seizures And Epilepsy Following Febrile Seizures


Sponsor

Pham Ngoc Thach University of Medicine

Enrollment

650 participants

Start Date

Mar 15, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to learn about the recurrence and development of epilepsy in children hospitalized with their first febrile seizures. The main questions it aims to answer are: * What is the risk of recurrence after the first febrile seizure and what are the risk factors for recurrent febrile seizures in Vietnamese children? * What is the risk of developing epilepsy later in life and what are the risk factors for developing epilepsy in Vietnamese children who have had febrile seizures?


Eligibility

Min Age: 1 MonthMax Age: 8 Years

Inclusion Criteria3

  • Children had a diagnosis of first febrile seizure based on the definition of the International League Against Epilepsy (ILAE) in 1993. That was a seizure occurring in childhood after one month of age associated with a febrile illness not caused by an infection of the central nervous system, without previous neonatal seizures or a previous unprovoked seizure, and not meeting the criteria for other acute symptomatic seizures. Fever is clinically a temperature of at least 38°C by any method as recorded either in the emergency department, outpatient clinics, or as noted in the medical history, as well as measured upon admission to the inpatient departments.
  • Patients were between 1 month and 8 years of age
  • Agreement from parents with written informed consent

Exclusion Criteria3

  • Febrile paroxysmal events were atypical for seizures
  • Underlying neurological conditions that increase the likelihood of epilepsy
  • Unwillingness to return for follow-up

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Locations(1)

Children's Hospital 2

Ho Chi Minh City, Vietnam

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NCT06444126


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