Cutaneous Squamous Cell Carcinoma (CSCC) Clinical Trials

9 recruiting

Cutaneous Squamous Cell Carcinoma (CSCC) Trials at a Glance

10 actively recruiting trials for cutaneous squamous cell carcinoma (cscc) are listed on ClinicalTrialsFinder across 6 cities in 6 countries. The largest study group is Phase 2 with 2 trials, with the heaviest enrollment activity in Houston, Indianapolis, and Boston. Lead sponsors running cutaneous squamous cell carcinoma (cscc) studies include Dana-Farber Cancer Institute, Fondazione IRCCS Policlinico San Matteo di Pavia, and Centre Leon Berard.

Browse cutaneous squamous cell carcinoma (cscc) trials by phase

Treatments under study

About Cutaneous Squamous Cell Carcinoma (CSCC) Clinical Trials

Looking for clinical trials for Cutaneous Squamous Cell Carcinoma (CSCC)? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Cutaneous Squamous Cell Carcinoma (CSCC) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Cutaneous Squamous Cell Carcinoma (CSCC) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 110 of 10 trials

Recruiting
Phase 3

Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

Cutaneous Squamous Cell Carcinoma (CSCC)
Regeneron Pharmaceuticals369 enrolled49 locationsNCT06585410
Recruiting
Phase 3

Study of a Strategy Integrating Adjuvant Radiation Therapy Versus Strategy Based on Monitoring in the Treatment of Carcinomas Spinocellular With High Risk of Recurrence

Cutaneous Squamous Cell Carcinoma (CSCC)
Centre Leon Berard266 enrolled28 locationsNCT06692556
Recruiting
Phase 1

A Study of VET3-TGI in Patients With Solid Tumors

Cervical CancerNon-small Cell Lung CancerHead and Neck Squamous Cell Carcinoma+10 more
KaliVir Immunotherapeutics60 enrolled7 locationsNCT06444815
Recruiting

Liquid Biomarker Study in Melanoma and Non-Melanoma Skin Cancers

Skin CancerMelanoma (Skin Cancer)Merkel Cell Carcinoma of Skin+3 more
University of Wisconsin, Madison20 enrolled1 locationNCT06608511
Recruiting

Tumor-Informed ctDNA Testing for MRD Following Treatment of Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and NeckCutaneous Squamous Cell Carcinoma (CSCC)Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)+1 more
University of California, San Francisco250 enrolled1 locationNCT06606028
Recruiting
Early Phase 1

A Phase 0 Window of Opportunity Trial of Intratumoral Seasonal Influenza Immunization in Cutaneous Squamous Cell Carcinoma (CSCC) Patients Awaiting Curative Excision

Cutaneous Squamous Cell CancerSkin CancerCutaneous Squamous Cell Carcinoma (CSCC)
Dana-Farber Cancer Institute25 enrolled2 locationsNCT06664151
Recruiting

Next-gen Flow Cytometry to Find Immune Profiles, Treatment Response, and Toxicity Markers in Skin Cancer Patients Treated With Cemiplimab.

Cutaneous Squamous Cell Carcinoma (CSCC)
Instituto de Investigación Biomédica de Salamanca30 enrolled1 locationNCT07064330
Recruiting
Phase 2

Phase 2 Pragmatic Trial of Sentinel Lymph Node Biopsy (SLNB) in Patients With Clinically Node-Negative (cN0), High-Risk Cutaneous Squamous Cell Carcinoma (cSCC) of the Head and Neck

Cutaneous Squamous Cell Carcinoma of the Head and NeckClinically Node-Negative (cN0)High-Risk Cutaneous Squamous Cell Carcinoma (cSCC) of the Head and Neck
University of California, Davis24 enrolled1 locationNCT06990737
Recruiting
Phase 2

Towards Cure Via Only Ultra-short ICB in CSCC

Cutaneous Squamous Cell CancerCutaneous Squamous Cell CarcinomaCutaneous Squamous Cell Carcinoma (CSCC)+1 more
The Netherlands Cancer Institute41 enrolled5 locationsNCT06823479
Recruiting

Usefulness of Post-Operative Radiotherapy in High-grade Cutaneous Squamous Cell Carcinoma: an Observational Study

Cutaneous Squamous Cell Carcinoma (CSCC)
Fondazione IRCCS Policlinico San Matteo di Pavia120 enrolled1 locationNCT06879964