Capsaicin in Digital Osteoarthritis Versus Control
Capsaicin in Digital Osteoarthritis Versus Control : a Randomized Study
University Hospital, Clermont-Ferrand
120 participants
Mar 7, 2025
INTERVENTIONAL
Conditions
Summary
The objective of this multicentric, randomized controlled double-blind clinical trial is to demonstrate the efficacy of transdermal application of capsaicin in patients with painful digital osteoarthritis with a neuropathic pain component. Participants will receive either a transdermal patch of capsaicin 179 mg (8%) or the control treatment (capsaicin 0.04%). Researchers will compare the intensity of pain in the fingers at day 60 in the capsaicin 8% group versus capsaicin 0.04% (control arm)
Eligibility
Inclusion Criteria4
- Diagnosis of digital osteoarthritis fulfilling the American College of Rheumatology criteria;
- Presence of finger pain of ≥ 40 mm on a visual analogue scale (VAS);
- Presence of finger pain with a neuropathic pain component (DN4 score ≥ 4/10)
- Inadequate response, adverse reactions, and/or contraindications to conventional analgesics and NSAIDs;
Exclusion Criteria11
- Patient with isolated rhizarthrosis;
- Patient with other joint disease affecting the fingers (gout, chondrocalcinosis, RA, spondyloarthritis, psoriatic arthritis);
- Patient with upper extremity pain syndrome that may interfere with the assessment of finger pain;
- Patient with another pathology responsible for neuropathic hand pain (carpal tunnel syndrome, diabetic neuropathy, Guyon's tunnel syndrome, cervicobrachial neuralgia, brachial plexitis);
- Patient with skin lesions on the fingers (psoriasis, wounds, chronic ulcers, eczema, shingles, dermatitis);
- Patient with poorly controlled high blood pressure;
- Patient with hypersensitivity to capsaicin;
- Patient who had 8% capsaicin patch use in the year prior to the study;
- Patient who has received intramuscular, intra-articular or intravenous corticosteroid therapy, another disease-modifying anti-rheumatic therapy (methotrexate, salazopyrine) or an intra-articular injection into the joints of the fingers within the previous 3 months;
- Patient wearing wrist or finger orthoses in the previous month;
- Patient with fibromyalgia;
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Interventions
patch application for 30 minutes on the painful fingers.
patch application for 30 minutes on the painful fingers. the low-dose patch has a similar appearance to the active patch. It allows you to keep the blind, because it also causes reactions at the capsaicin application site (erythema, burning).
Locations(4)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06444919